In multicellular organisms, each cell is influenced by the others in its surrounding environment, and the maintenance of cellular and tissue spatiality – or lack thereof – carries significant ...

This illustration summarizes how integrated spatial transcriptomics, single-cell transcriptomics, single-cell epigenomics, and spatial epigenomics enable multi-dimensional profiling of the tumor ...

Spatial biology has rapidly reshaped tissue analysis, but most methods still rely on thin two-dimensional (2D) slices, giving fragmented glimpses of complex tissue structures. As spatial ...

A collaborative project has created a comprehensive guide to help standardize spatial transcriptomics practices. Spatial transcriptomics provides a unique perspective on the genes that cells express ...

Perturb-FISH aims to address both challenges. Because this technique harnesses imaging spatial transcriptomics (iST), it offers high resolution and scalability, as well as relatively low costs. To ...

Researchers at Helmholtz Munich and the Technical University of Munich (TUM) have developed Nicheformer, the first large-scale foundation model that integrates single-cell analysis with spatial ...

LatchBio provides white-labeled data infrastructure, analysis tools and delivery portals for kit, instrument, and solution providers. Today, LatchBio released a 25 million cell spatial atlas spanning ...

The architecture of tissues is defined by the spatial organization of their cells. Probing how cells affect one another in a spatial context holds vast potential for understanding health and disease.

New simulator and computational tools generate realistic ‘virtual tissues’ and map cell-to-cell ‘conversations’ from spatial transcriptomics data, potentially accelerating AI-driven discoveries in ...

The rapid development of spatial transcriptomics (ST) technologies has greatly advanced the understanding of gene expression, tissue architecture, cellular composition, and disease mechanisms within ...